17 Effects of Growth Hormone Secretagogue In Bodybuilding

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What is a growth hormone secretagogue, also known as an HGH secretagogue?

How is it used by bodybuilders or athletes?

Do benefits outweigh the risk of use?

A secretagogue is defined as something that triggers or encourages a specific activity in the body.

An HGH secretagogue can be defined as a product can be a dietary supplement that encourages the production and secretion of growth hormone from the pituitary gland.

It can also be drug-based, which essentially adds to or replaces natural growth hormone.

HGH Secretagogue Review

What are the benefits of growth hormone secretagogues?

Because of the function of growth hormone in the body, amplification of triggering pulsations of growth hormone is perceived to provide a number of benefits for bodybuilders and athletes.

Among them:

Faster metabolism

Increased levels of growth hormone and IGF-1

Development of leaner body mass

Boost in energy

Enhanced nitrogen retention in muscles

Improved sleep patterns

Efficient immune system responses

Growth Hormone Function In The Body

Growth hormone is manufactured in the pituitary gland. Growth hormone also has an influence on other hormones such as:



Insulin-like growth factor-1 (IGF-1)



Bodybuilders often turn to prescription-strength products that accelerate muscle mass gains, improve physical performance, and provide protection to muscles.

One option is prescription-strength drugs including anabolic androgenic steroids like Stenbolone that mimic the effects of testosterone.

They also use injectable and prescription-strength growth hormone, and insulin-like growth factor/s.

Prescription-strength drugs can be quite expensive, depending on how they’re procured, and they can also trigger a number of undesired side effects such as steroid gut.

Another option is to use nutritional supplements known as HGH releasers, pro-hormones, or precursors.

These products contain a number of amino acids and peptides that support pituitary gland function. They don’t substitute for natural growth hormone.

The main difference between a growth hormone secretagogue and an injection (prescription-strength) HGH injection is a matter of safety.

The HGH secretagogue product will encourage natural release of growth hormone by the pituitary gland.

The injection (prescription-strength) HGH injection is adding to growth hormone levels in the body, sometimes to extreme levels.

Natural growth hormone is released in pulses by the pituitary gland, mainly during sleep.

Growth hormone injections release a surge of growth hormone into the bloodstream from the injection site.

Bodybuilding Growth Hormone Secretagogue

It’s not particularly uncommon to find bodybuilders turning to growth hormone secretagogue use.

Why? Because it’s rated as one of the three “necessary” anabolic hormones produce muscle and enhanced muscular appearance, as well as improved stamina and endurance desired by bodybuilders.

These three hormones:

Growth hormone

Insulin-like growth factor-1


This combination of hormones is often called the triad of bodybuilding hormones.

When it comes to safety, growth hormone secretagogue use doesn’t tend to produce the often-alarming side effects associated with synthetic growth hormone injections.

Most often, they come in oral form and boost the release of endogenous (body-produced) growth hormone in the typical pulses associated with normal function.

One of the most commonly ones used these days is known as MK-677. Otherwise known as Nutrobal (also known by its chemical name Ibutamoren), this HGH secretagogue sends chemical signals to the pituitary gland to release growth hormone.

It’s an oral growth hormone secretagogue that has undergone a number of studies and a clinical trial (MK-0677); one of interest in the treatment of female fibromyalgia.

What About Dosage?

Dosage recommendations differ depending on form. For example, injections of MK-677 is typically used by bodybuilders in a 25 mg dose daily for approximately 8 weeks.

Growth hormone secretagogue products are not typically used by themselves, but combined with other products including Cardarine to enhance metabolism, improve endurance, and promote energy.

Growth hormone secretagogues like MK-677 are also combined with other selective androgen receptor modulators (SARMs) such as Andarine for fat loss.

Other brands include MHP Secretagogue Gold, Secretagogue One and HGH Plus.

Some bodybuilders stack HGH secretagogue products with anabolic androgenic steroid use, with varying results.

A stack combining growth hormone secretagogue and Cardarine and Andarine will vary in regard to dosage recommendations. A sample 10-week cycle may look something like this:

Neutrobal/MK 677 – 25 mg daily for 10 weeks

Cardarine – 20 mg daily for 10 weeks

Andarine – starting at 25 mg daily and increasing in 5 mg increments up to 70 mg daily by week 10

Growth Hormone Secretagogue Side Effects?

HGH secretagogue side effects from usage depends on individual reactions.

Injectable growth hormone secretagogue use may trigger more side effects than the dietary supplement, precursor or pro-hormones that contain natural ingredients.

Disrupting hormone levels in the body or triggering higher than normal levels of growth hormone in the body can potentially lead to a number of side effects that include:

Joint pain

Muscle pain

Nerve pain

Numbness or tingling sensations on the skin


Before using growth hormone secretagogue products, research the brand, its ingredients, and consider safety issues. Always weigh benefits as opposed to potential drawbacks with use.

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