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What is IGF-1 LR3?
IGF-1 LR3 stands for insulin-like growth factor-1, long Arg 3.
It’s also found written like this: IGF-1 Lr3.
This compound belongs to the family of protein peptides that function to promote growth and development.
This growth not only applies to muscle and bone, but other cells in the body.
In medical and scientific research scenarios, it’s also called Long R3 IGF-1.
Outside of the context of medical research, this amped up version of IGF-1 is sought after by bodybuilders who want to achieve new levels in their fitness routine.
What Does IGF-1 LR3 Do?
IGF-1 LR3 is more potent than insulin-like growth factor-1, manufactured in the liver.
Insulin-like growth factors have binding proteins that enable certain functions, but this modified version (LR3) has decreased binding capabilities.
Under typical circumstances, this serves to inhibit activities or biological functions of insulin-like growth factors.
Because of this inhibition, IGF-1 LR3 increases in potency, its ability to function, and in regard to efficacy.
More specifically, IGF-1 LR3 is known as a human, single, non-glysolated, recombinant, polypeptide chain that contains 83 amino acids. 
Insulin-like growth factor is manufactured in the liver, triggered by the production and secretion of growth hormone manufactured in the pituitary gland, located in the brain.
This growth factor (IGF-1) is involved with mediation of many of the growth promoting activities of growth hormone.
In medical research scenarios, IGF-1 LR3 is an analog or compound similar to that of human IGF-1 most commonly used in the manufacture and development of biopharmaceuticals, especially those utilizing recombinant DNA technologies.
The primary mechanism of action of IGF-1 LR3 involves its protein structure.
This compound is the main protein that plays a role in its response to growth hormone as it applies to cellular proliferation, differentiation, and growth and development.
How does this work? Insulin-like growth factor-1 is secreted by the liver, as mentioned, in response to the secretion of growth hormone into the body.
The combination of these two compounds triggers cellular activities, including muscle growth (known in medical speak as hyperplasia).
Usage of IGF-1 LR3 by Bodybuilders and Athletes
While designed for medical research purposes, the compound is often coveted by bodybuilders and athletes, who find it on the black market.
It’s extremely potent, and though a number of bodybuilders and athletes believe that injecting growth hormone into the body is safer than using anabolic androgenic steroids, this isn’t necessarily true.
Growth factors and human growth hormone can trigger growth and development of muscle cells, but it doesn’t do anything to make those cells stronger.
The name “insulin-like growth factor” is given because it’s similar in structure, activity, and potentially side effects associated with the hormone insulin. Higher or lower than normal levels of insulin, which functions as a vehicle for transportation of glucose or energy to reach cells in the body can trigger unexpected complications.
Quite simply, IGF-1 LR3 is basically a modified form of IGF-1.
Endogenous growth hormone produced by the pituitary gland contains a specific sequence of 191 amino acids.
IGF-1 contains 70 amino acids, plus modification of an additional 13 amino acids.
Medical sources and bodybuilders both believe that IGF-1 LR 3 is between two to three times stronger or potency than IGF-1. 
Benefits of Use
What can a bodybuilder expect in regards to benefits associated with use of IGF-1 LR3?
Quite simply, acceleration in the development of muscle tissue, most especially in the region where the injection has been given.
This can be beneficial to professional bodybuilders prior to a competition, but the substance is universally banned.
Another benefit is the long half-life of IGF-1 LR3. That half-life extends up to 30 hours, quite a bit longer than the relatively short half-life of “regular” IGF-1.
While its popularity has slowly increased over the past few years, IGF-1 LR3 is still difficult to get your hands on, depending on resources and geographical region. It’s mainly used in research laboratories and is definitely not recommended by medical professionals for nonmedical purposes.
Bodybuilders looking for IGF-1 LR3 can find it online, although caution is always advised.
Caveat: Testing positive for any growth factor or anabolic androgenic steroid or derivatives can trigger disqualification as well as potential banishment by a number of sporting organizations around the world.
Side Effects Associated with IGF-1 LR3
Because of its potency, IGF-1 LR3 has the potential to not only accelerate development of muscle mass, but type and severity of its side effects. However, because it’s not that commonly used in non-medical or research environments, information regarding how severe the site effects are still widely unknown.
Comparing side effects to those generally seen with IGF-1 is a good place to start. Just a few include:
Disruption of hormone levels in the body, which can not only interfere with hormone activities and body organ systems and functions, but take months to get under control.
Pain in muscles, bones, joints, and nerves
Before turning to IGF-1 LR3, be aware of the dangers of injecting a very potent growth hormone into a body whose hormone levels already adequate.