RHGH Review—Dosage & Side Effects of Human Growth Hormone for Bodybuilding

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What is RHGH and how can it benefit bodybuilders?

Bodybuilders may be more familiar with the term written as rHGH, which stands for recombinant human growth hormone.

What is it, and how does it differ from growth hormone manufactured by the body?

Does a bodybuilder even need rHGH to achieve results in muscle development and overall physique as well as performance enhancement?

We will explain more about the nature of rHGH and how it compares to other forms of HGH.

The Difference Between rHGH and Endogenous HGH

Endogenous or body-produced HGH (human growth hormone) is manufactured and the pituitary gland, located at the base of the brain.

It’s called somatotropin.

Unless a person is born with a genetic issue or some type of deficiency, or damage to the pituitary gland occurs, growth hormone manufacture, secretion, and levels are adequate through childhood, adolescence, and into adult life.

Body-produced human growth hormone contains 191 amino acids arranged in a specific chain sequence. Amino acids are essential for a number of processes in the body, including synthesis of proteins.

Of interest to bodybuilders is that protein is essential for the production or synthesis of new muscle growth, development, and health.

Recombinant HGH (rHGH) is manufactured in a laboratory by combining (recombinant) two or more genetic strands of DNA to create synthetic HGH – with an identical structure as that of endogenous HGH. Synthetic HGH is known as somatropin.

In some ways, recombinant DNA technology is similar to cloning, but is focused on creating “substitutes” or substances that are similar to the product they’re trying to replicate.

For example, rHGH is not some obliquely created substance similar to the functions and activities of endogenous growth hormone.

Synthetic rHGH defines molecular cloning that utilizes a fragment of DNA from one source and a fragment of the human growth hormone gene to create a substance that is identical in nature and function as body-produced growth hormone.

Manufacturing rHGH

Over two dozen brand-name, synthetic growth hormone products are available for medical treatments today, manufactured by well-known pharmaceutical companies including Merck, Pfizer, and Novo Nordisk.

Different manufacturers may utilize different strands of DNA in combination with the HGH gene to create their products.

Recombinant DNA technologies are extremely expensive, require expertise, and high-tech equipment.

These technologies are commonly used in the development of pharmaceutical grade and government approved drugs, biotechnology, and in medical research. It’s a form of genetic engineering.

For example, some companies combine the human growth hormone gene with some type of bacteria strain such as E. coli to create the rHGH. Other companies may use a mouse cell line, while still others may use something else.

What About Use of rHGH by Bodybuilders?

rHGH is intended only as a prescription-strength drug used to replace growth hormone not manufactured in adequate amounts by the pituitary gland.

Growth hormone injections are most often indicated for children and adolescents, and in a lesser degree of frequency in adults, depending on situation.

Growth hormone makes things grow, and bodybuilders often turn to such products to accelerate and enhance their muscle building and muscle growth as well as physique results.

This is not recommended, as introducing exogenous growth hormone into the body when it is not required can trigger a number of unpleasant side effects and enters reactions.

A number of clinical trials have been conducted on rHGH as well as its combination with synthetic insulin-like growth factor-1 (IGF-1) in the treatment of children diagnosed with short stature caused by IGF-I or growth hormone deficiencies.

It should be noted that such clinical trials do not accept “healthy” volunteers [1].

Bodybuilders tempted by the benefits of rHGH on efforts may ignore warnings, but determining a safe dosage is risky.

Dosage Recommendations for rHGH

In medical scenarios, manufacturers generally start dosages for treatment at .01 mg per kilogram of body weight. In some cases, and depending on condition being treated, dosage is increased incrementally over the course of treatment, which may last anywhere from 12 weeks to six months, or more.

Dosage recommendations for rHGH found on the Internet are often twice, three times, and sometimes even more than that recommended in a medical treatment scenario.

Bodybuilders tend to take higher than recommended dosages for accelerated benefits. Even taking low-dose growth hormone over a short period of time can contribute to a number of undesired side effects.

rHGH Side Effects

Higher than normal levels of HGH in the body, whether it’s produced by the pituitary gland or an injection of rHGH, can contribute to a number of negative side effects and adverse reactions.

Among them include:

Carpal tunnel syndrome

Joint pain

Nerve or muscle pain


Impaired glucose tolerance

Potential for gynecomastia

These are just a few of the side effects associated with monitor rHGH. Before use, take the time to research and carefully weigh the benefits as opposed to the potential development of side effects.

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