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Somatotropin hormone, more commonly known as human growth hormone or hGH/HGH, is manufactured in the pituitary gland
It is located in the brain. As its name implies, it’s responsible for growth.
Growth of linear length of bones is just one of the numerous capabilities of somatotropin.
Somatotropin, like many hormones, is amino acid-based.
Growth hormone is defined as a protein peptide constructed of long polymers of amino acids – 191 amino acids to precise, arranged in a specific sequence.
Somatotropin Hormone Primer – In Brief
Human growth hormone is manufactured in the anterior lobe of the pituitary gland.
Manufacture and release of growth hormone is overseen by the hypothalamus, also located in the brain and directly connected to the pituitary gland.
In turn, the pituitary gland, called the master gland of the body, is also responsible for the maintenance, production, and secretions of other hormones.
This includes those of the thyroid, the adrenal cortex, and the gonads.
Growth hormone also stimulates production of growth factors, including IGF-1, from the liver.
These hormones, working in conjunction with one another and others, are what provide the body with the ability to grow from the tiniest muscle cell to entire organs and organ systems.
The unique ability of somatotropin hormone to target specific receptor proteins on cellular membranes, including that of muscle, encourages muscle growth and development.
This is a priority when it comes to bodybuilding and athletic performance enhancement.
How Does Somatotropin Hormone Work in the Body?
The function of the hypothalamus and the manufacture and secretion of growth hormone is complex.
Hypothalamus neurons can synthesize both release of or trigger the manufacture of a hormone, as well as instructions through neurotransmitter signals to inhibit or decrease hormone production. Just a couple of those include:
Growth hormone releasing hormone (GHRH)
Growth hormone inhibiting hormone (GHIH)
When the hypothalamus releases growth hormone releasing hormone neurotransmitters, it stimulates the production of growth hormone or somatotropin hormone.
A number of triggers can stimulate this response including exercise, stress, and decreased levels of amino acids.
When adequate levels of growth hormone are sensed by the hypothalamus, it can decrease or inhibit further secretions of growth hormone and insulin-like growth factors through growth hormone-inhibiting hormone known as somatostatin.
Somatotropin hormone targets specific organs in the body and provides specific effects.
Major target organs of growth hormone include muscle, cartilage, bone, and the liver.
It’s an anabolic hormone that stimulates somatic growth.
It also mobilizes fat. The growth promoting effects of growth hormone are themselves mediated indirectly by insulin-like growth factors, manufactured in the liver.
Mechanism of Action
Somatotropin hormone, once released, can provide a number of direct as well as indirect actions. Its direct actions, which are metabolic in nature, include:
Metabolism of fats, contributing to an increase in breakdown of fats
Metabolism of carbohydrates, which increases levels of blood glucose and other anti-insulin effects.
Indirect actions of growth hormone are known as growth-promoting. Levels of growth hormone stimulate the liver to manufacture insulin-like growth factors.
These effects can be noted on both skeletal and extraskeletal processes.
Skeletal: increased skeletal growth as well as enhanced formation of cartilage.
Extraskeletal: enhanced synthesis of proteins, cellular growth, and proliferation.
Because somatotropin is anabolic or tissue-building in nature, it has a direct influence on both metabolism as well as muscle development and other body processes.
This all sounds beneficial for bodybuilders and athletes who might be considering injecting growth hormone for accelerated physical enhancement, performance, or physique.
However, disrupting otherwise normal hormonal balances in the body can contribute to a number of negative side effects and adverse reactions.
Higher than average or erratic levels of somatotropin hormone in the body can contribute to a number of issues.
Levels of growth hormone secretions occur in spurts throughout a daily cycle, with the highest levels of growth hormone secreting and functioning during sleep.
Abnormal levels and secretions of somatotropin hormone can contribute to acromegaly, defined as enlarged extremities.
Acromegaly is typically identified by out-of-control and overgrowth of the bones, muscles, and connective tissues in the feet, the hands, and the face.
This is one of the most serious dangers of prescription strength and non-supervised nor medically necessary injections of synthetic growth hormone.
Other side effects associated with somatotropin hormone can depend on what other hormone functions are affected.
An imbalance of one hormone in the body has a direct influence on the manufacture and secretions of other hormones as well.
It’s extremely difficult to get hormone balances back into balance, even in medically supervised treatments.
Somatotropin hormone is vital to growth and development, not only of bone and muscle, but tissues and organs.
Before considering use of any form of growth hormone, take the time to understand how it works and how many other processes it’s involved in.