Synthetic HGH—What does HGH do for bodybuilders?

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Synthetic HGH (human growth hormone) is called somatropin.

Growth hormone is manufactured by the body, and is known as somatotropin.

It’s not uncommon to find synthetic forms of hormones manufactured in laboratories.

This type of development is designed to replace hormones that aren’t manufactured and secreted in adequate amounts by the body.

These drugs are legal with a prescription and are available as therapeutic treatments, especially for growth deficiencies.

But as the name implies, human growth hormone supports the growth of muscle tissue and bone cells. That has helped synthetic somatropin gain some popularity with bodybuilders looking to reach new heights in their fitness routines.

But using synthetic HGH for bodybuilding is not without risks, both legal and health-wise

Synthetic HGH VS. “Real” HGH

When manufactured by a legitimate pharmaceutical company, the difference between “real” and synthetic HGH is only a matter of how it is produced.

Endogenous or body-produced human growth hormone (HGH) is manufactured in the anterior lobe of the pituitary gland.

Endogenous growth hormone is defined as a peptide hormone that stimulates not only bone and muscle growth, but growth of all cells in the body.

It’s also vital in cellular reproduction, differentiation, and regeneration.

Levels of growth hormone in the body are typically highest during childhood and adolescent development as the body increases in stature and works in combination with other growth hormone and growth factors such as those produced by the thyroid, the testes, and the ovaries.

Synthetic or laboratory created growth hormone is developed by using an actual human growth hormone gene that is combined with another type of component such as bacteria or a cellular structure from an animal that multiplies into a form that is identical to that of human growth hormone.

For example, human growth hormone contains 191 amino acids, one of the major structures of the growth hormone protein.

High quality and legitimate manufacture of synthetic growth hormone (somatropin) also contains the 191-amino acid polypeptide hormone.

Synthetic growth hormone is specifically designed to replace growth hormone that is not manufactured in adequate amounts, mainly in children. Therapeutic treatments of growth hormone focus on growth hormone deficiencies that can lead to dwarfism, idiopathic short stature, and failure to thrive.

Manufacturing Synthetic HGH

Synthetic HGH is manufactured through a number of methods and technologies, as well as the combinations of components.

Legitimate synthetic HGH is manufactured utilizing recombinant DNA (rDNA) technologies.

Recombinant DNA technologies are an invaluable process in sequencing genetic codes in a laboratory that is similar to cloning.

Specifically, rDNA technologies combine two or more gene sequences to engineer a drug, such as growth hormone, that adequately substitutes or replaces growth hormone in the body.

Major pharmaceutical laboratories may utilize different rDNA technologies to manufacture their brands of growth hormone.

For example, some manufacturers combine a human growth hormone gene or factor with some type of bacteria such as E. coli, while others will use a mouse cell line.

In the dairy industry, recombinant bovine growth hormone has been used in the past to stimulate milk production in dairy cows.

Benefits of Use

Synthetic HGH provides a number of benefits not only for children diagnosed with a growth hormone deficiency, but adults as well.

For bodybuilders, synthetic HGH injections can also provide a number of benefits including:

Accelerated development of lean muscle mass

Decrease in fat stores

Increased energy

Improved retention of nitrogen in the muscles

While synthetic HGH can benefit athletes and bodybuilders, it is not recommended. Injecting a hormone into the body when it doesn’t need it can contribute to a number of side effects and adverse reactions.

Synthetic HGH available from underground labs and black-market resources, as a lot of it is fake and contains questionable ingredients.

Dosage recommendations for synthetic HGH depend on the brand and its milligram strength.

Bodybuilders should also note that while synthetic HGH may provide benefits in regard to development of lean muscle mass, it won’t make the muscles stronger.

Side Effects Associated with Synthetic HGH

A number of side effects have been associated with use of synthetic HGH. This even applies to medical treatments when dosage and results are carefully monitored by a physician.

Side effects are not always dosage dependent. Adverse reactions can be influenced by a number of factors that include:



Genetic history

Body type


Side effects of synthetic HGH can range from transient and mild to severe; sometimes severe enough to cause long-term damage to the body.

Among the most common side effects associated with HGH injections, users may experience:

Headaches that can range from mild to severe

Muscle pain (at times localized, other times spread throughout an extremity)

Joint pain – resulting in stiffness, lack of range of motion, and weakness

Overall sense of fatigue

Weight gain (typically caused by fluid retention) but may also be caused by hormone imbalances

Some bodybuilders using synthetic HGH also experience bloating, typically known as the HGH bloat or HGH face.

Accelerated growth of intestinal tissues can result in enlarged intestines and a protruding abdomen.

Use of synthetic HGH can also contribute to metabolic imbalances and hormone disorders that can be difficult to get under control.

Even at low doses, synthetic HGH does interact with other hormones and imbalances and can lead to a myriad of problems.

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